Durabolin injection side effects is a selective agonist of β 2 adrenoceptor. At therapeutic doses it acts on the β 2 adrenergic receptors of smooth muscles of the bronchi, providing little or no effect on β 1 adrenergic receptors of myocardium. Has a pronounced bronchodilator effect of preventing or arresting bronchospasm, reduces the resistance in the airways. It increases lung capacity. Increases mucociliary clearance (in chronic bronchitis to 36%), stimulates the secretion of mucus, activates the function of the ciliated epithelium. The recommended therapeutic doses has no adverse effect on the cardiovascular system, it causes high blood pressure. To a lesser extent, as compared with the drugs of this group has a positive chrono – and inotropic effects. It is an extension of the coronary arteries. It has a number of metabolic effects: reduces the concentration of potassium in the plasma affects glycogenolysis and insulin release, has a hyperglycemic (especially in asthmatic patients) and lipolytic effect, increases the risk of acidosis. When inhaled forms of action develops quickly, beginning effect – in 5 min, max – after 30-90 min (75% of the maximum effect is reached within 5 min), duration -. 4.6 h Pharmacokinetics . After inhalation 10-20% durabolin injection side effects dose reaching the lower respiratory tract. The rest of the doses remain in the inhaler or is deposited in the oropharynx and then swallowed. The fraction deposited in the airways is absorbed into the pulmonary tissues and blood, but it is not metabolized in the lungs. The degree of binding of durabolin injection side effects to plasma proteins is approximately 10%. Once in the blood, durabolin injection side effects undergoes hepatic metabolism and is excreted primarily anaboliczstore in the urine in unchanged form or a phenolic sulfate. swallowed part of the inhalation dose absorbed from the gastrointestinal tract and undergoes metabolism in the active “first pass through the liver” transforming into phenol sulfate. Conjugate and unmodified durabolin injection side effects predominantly excreted in the urine. Introduced durabolin injection side effects intravenously has a half-life 4 -. 6 hours is derived partly kidneys and partly as a result of metabolism to inactive 4′-O-sulphate (phenolic sulphate), which also appears mainly in urine. With the feces excreted deca injection results by only a fraction of the administered dose of durabolin injection side effects. Most of the dose of durabolin injection side effects administered to the body intravenously, orally or by inhalation, is excreted within 72 hours.
Indications for use
1. Asthma – relief of asthma attacks, including an exacerbation of bronchial asthma heavy currents; – prevention of attacks of bronchospasm associated with exposure to the allergen, or caused by physical exertion. – Use as a component in long-term maintenance treatment of asthma. 2. Chronic obstructive pulmonary disease (COPD), accompanied by reversible airway obstruction, chronic bronchitis.
Contraindications – Hypersensitivity to any component of the formulation. – Management of preterm labor. – Threatened abortion. -. Children under 2 years of age with caution to use the drug if patients have a history of tachyarrhythmia, myocarditis, heart defects, aortic stenosis, coronary artery disease heart, severe chronic heart failure, hypertension, hyperthyroidism, pheochromocytoma, decompensated diabetes, glaucoma, epipripadki, renal or hepatic insufficiency, concomitant use of nonselective β-blockers, pregnancy, lactation.
Pregnancy and lactation Pregnant women drug is given only if the expected benefit to the patient outweighs the potential risk to the fetus. During post-marketing surveillance revealed rare cases of various congenital malformations in children, including the formation of a “cleft palate” and limb malformations, while taking their mothers during pregnancy, durabolin injection side effects. In some of these cases, the mother taking multiple concomitant medications during pregnancy. The causal relationship to drug intake has not been established. durabolin injection side effects is likely to pass into the breast milk and therefore it is not recommended for lactating women except those. cases kogda.ozhidaemaya benefit for most patients outweighs the potential risk to the child. No data is provided if present in breast milk durabolin injection side effects harmful effect on the newborn.
Dosage and administration metered aerosol Ventolin is only intended for administration by inhalation. To solve the problem of increasing the dose or frequency of use of the drug can only be a doctor. Not recommended for use Ventolin inhaler more than 4 times a day. The need for frequent use of maximum doses of Ventolin or a sudden increase in dose indicates deteriorating course of the disease.Adults (including elderly patients) . Cupping bronchospasm: the recommended dose is 100-200 mg (1-2 inhalations). Preventing attacks of bronchospasm, related to exposure to allergen or exercise-induced: the recommended dose is 200 mg (2 inhalations) for 10-15 minutes before exposure to a provoking factor. Long-term maintenance therapy: The recommended dose is 200 mg (2 inhalations) 4 times a day. Children . Cupping bronchospasm attack: the recommended dose is 100-200 mg (1-2 inhalations). Preventing attacks of bronchospasm associated with exposure to the allergen or exercise-induced: the recommended dose is 100-200 mg (1-2 inhalations) for 10-15 minutes before exposure . provoking factor Long-term maintenance therapy:. The recommended dose is 200 mg (2 inhalations) 4 times a dayVentolin can enter “Bebihaler” via a spacer.
Instructions for use of the inhaler inhaler Checking before first use of the inhaler, or if the inhaler is not used a week or longer, remove the cap from the mouthpiece, slightly squeezed cap laterally, shake the inhaler and press the valve of the aerosol for the release of one inhalation dose in the air, to ensure that the health of the inhaler. Using the inhaler 1. Remove the cap from the mouthpiece, gently squeezing the cap on the sides. 2. Inspect the mouthpiece inside and outside to make sure it was clean. 3. Shake the inhaler. 4. Hold the inhaler between finger and thumb in a vertical bottom-up position, with the thumb should be placed on the basis of a mouthpiece. 5. Take a slow deep breath, hold the mouthpiece with his lips, not clenching his teeth. 6. Making the most deep breath through your mouth at the same time press the top of the inhaler to release one dose of inhaled durabolin injection side effects. 7. Hold your breath for a few seconds, remove the mouthpiece from the mouth, then exhale slowly. 8. For the second dose, holding the inhaler in a vertical position, wait 30 seconds and then repeat step 3-7. 9. Close the mouthpiece protective cap. Warning! Performing step 5, 6 and 7, you can not rush. It should begin to breathe in as slowly as possible just before pressing the inhaler valve. In the first few times it is recommended to practice before the mirror. If you see “mist” coming from the top of the inhaler or from the corners of the mouth, then you should start again from step 3. If your doctor has given you other instructions on the use of the inhaler, then obey them. Contact your doctor if you have difficulty using an inhaler. Clean nebulizer inhaler should be cleaned at least once a week. 1. Remove the metal canister from the plastic casing and remove the mouthpiece. 2. Thoroughly rinse the plastic case and the mouthpiece cover under warm running water. 3. Dry the plastic case and the mouthpiece cover fully both outside and inside. Avoid excessive heat. 4. Place the metal canister in a plastic casing and put the lid on the mouthpiece. Do not immerse the metal canister into water.
Adverse reactions are listed according to the anatomical and physiological classification and frequency of occurrence, which is defined as follows: very common (≥1 / 10), commonly (≥1 / 100 and <1/10), occasionally (≥1 / 1000 and <1/100), rare (≥1 / 10,000 and <1/1000) and very rare (<1/10 000), including isolated cases. immune system: very rare: hypersensitivity reactions, including angioedema, urticaria , bronchospasm, hypotension and collapse. On the part of metabolism: rarely hypokalemia. Therapy β 2 agonists may lead to significant hypokalemia. Very rare: Lactic acidosis. Very rare cases of lactic acidosis have been reported in patients receiving intravenous durabolin injection side effects Ventolin and nebula for the treatment of exacerbations of asthma. From the nervous system: common: tremor, headache; very rare: hyperactivity. Cardio-vascular system: common: tachycardia; sometimes: palpitations (pulsation, palpitation); rare: expansion of peripheral vascular disease; very rare: arrhythmias, including atrial fibrillation, supraventricular tachycardia and extrasystoles. The respiratory system, organs, thoracic and mediastinal disorders: very rare: paradoxical bronchospasm. On the part of the gastrointestinal tract: sometimes irritation of the mucous membranes of the mouth and throat. On the part of the bone -Muscular system: sometimes: muscle cramps.
Symptoms of overdose: more frequent – hypokalemia, lowering blood pressure, tachycardia, muscle tremors, nausea, vomiting; less frequent – excitement, hyperglycemia, respiratory alkalosis, hypoxemia, headache; -gallyutsinatsii rare, seizures, tachyarrhythmias, ventricular flutter, expansion of peripheral blood vessels. In case of overdose of durabolin injection side effects best antidotes are cardioselective β-blockers. However, β-adrenergic blockers should be used with caution in patients with episodes of bronchospasm in history. The use of high doses of durabolin injection side effects can cause hypokalemia, so you should monitor the level of potassium in the blood serum of a suspected overdose.
Interactions with other medications is not recommended to simultaneously use durabolin injection side effects and non-selective blockers, β-adrenergic such as propranolol. durabolin injection side effects is not contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs). In patients with hyperthyroidism increases the effects of central nervous system stimulants, tachycardia. Theophylline and other xanthines while the application increases the risk of tachyarrhythmias; means for inhalation anesthesia, levodopa – severe ventricular arrhythmias. Co-administration of anticholinergic drugs (in Vol. H. Inhalants) can increase intraocular pressure. Diuretics and corticosteroids enhance gipokaliemicheskoe effect of durabolin injection side effects.
Special instructions should instruct patients on the correct use of the inhaler Ventolin. Bronchodilators should not be the sole or main component of asthma therapy unstable or heavy current. If the action of the usual dose of Ventolin becomes less effective or less long (effect of the drug should be kept at least 3 hours), the patient should consult a doctor. Increasing demand for the use of inhaled β-agonists 2 -adrenoceptor with a short duration tamsulosin overdose of action for the control of asthma symptoms indicative of an exacerbation of the disease. In such cases, you should review the patient’s treatment plan. Sudden and progressive deterioration of asthma can be a threat to the patient’s life, so in such cases it is necessary to urgently address the issue of the appointment or increasing doses of corticosteroids. In these patients, it is recommended to carry out daily monitoring of peak expiratory flow rate. durabolin injection side effects should be used with caution in patients with thyrotoxicosis. Therapy agonists β 2 adrenoceptor, particularly when administered parenterally or via a nebulizer, can lead to hypokalemia. It advised to exercise special care when treating severe asthma attacks, since in these cases, hypokalemia may be enhanced by the simultaneous use of xanthine derivatives, corticosteroids, diuretics, and also due to hypoxia. In such situations it is necessary to control the potassium level in the blood serum.
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